Cardiopulmonary and hemodynamic changes in complement activation-related pseudoallergy
نویسندگان
چکیده
منابع مشابه
Cardiopulmonary and hemodynamic changes in complement activation-related pseudoallergy
Complement activation-related pseudoallergy (CARPA) is a frequent side effect of intravenous therapies with nanoparticle-containing drugs and biologicals that are recognized by the immune system as foreign. It is an acute infusion reaction dominated by cutaneous and hemodynamic changes, most significantly a cardiopulmonary distress involving major pulmonary hypertension, systemic hypotension an...
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A major goal in modern pharmacotechnology is to increase the therapeutic index of drugs by using nanoparticulate vehicle systems in order to ensure slow release or targeted delivery of drugs. With all great benefits, however, these innovative therapies can carry a risk for acute immune toxicity manifested in hypersensitivity reactions (HSRs) that do not involve IgE but arises as a consequence o...
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ژورنال
عنوان ژورنال: Health
سال: 2013
ISSN: 1949-4998,1949-5005
DOI: 10.4236/health.2013.56138